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BOOK SUMMARY :

Dendrimers for drug delivery and targeting the precise control over the distribution of drugs is highly valuable to abolish the typical drawbacks of traditional medicine thus a drug delivery system should be designed to attain the site specific delivery preferentiallythe expression dendrimer is derived from a greek term dendron that means tree which is logical in view of their typical structure with a number of branching units dendrimers are defined as synthetic macromolecules characterized by high branching points three dimensional globular shape monodispersity and nanometric size rangedendrimers for drug delivery are employed using two approaches i formulation and ii nanoconstruct in the formulation approach drugs are physically entrapped in a dendrimer using non covalent interactions whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach we have demonstrated the utility of pamam dendrimers due to their nanometric size dendrimers have been considered as potentially suitable as new vehicles for drug delivery since their infancy the association of a dendrimer and a drug may occur in different ways either through covalent or non covalent interactions a non covalent interaction can be the simpl jmc b top picks collection recent advances in drug deliveryfigure 2 dendrimer and dendron advantages of dendrimers 1 in target drug delivery dendrimers are suitable for targeting solid tumours due to increased permeability limited drainage in tumour vasculature which will lead to accumulation of macromolecules in tumour enhanced permeation rate

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